UNIV - Staff Scientist I - Department of Biochemistry

Company: Medical University of South Carolina
Location: Charleston
Posted on: April 1, 2026

Job Description:

Job Description Summary Applications are invited for a full-time Staff Scientist position available in the O’Bryan lab in the Department of Biochemistry and Molecular Biology at the Medical University of South Carolina and Hollings Cancer Center. Entity Medical University of South Carolina (MUSC - Univ) Worker Type Employee Worker Sub-Type? Research Grant Cost Center CC000954 COM BIOCHEM Operations CC Pay Rate Type Salary Pay Grade University-00 Pay Range 0.00 - 0.00 - 0.000 Scheduled Weekly Hours 40 Work Shift Job Description The successful candidate will be a highly motivated individual with excellent analytical and communication skills who has an interest in studying therapeutic resistance in cancer. The goal of our research program is to understand the complex signaling networks that regulated resistance to KRAS inhibition. We study the role of oncogenic KRAS in human cancer cells, using diverse methodology, including protein biochemistry, live cell imaging, pharmacological approaches, in vivo models and novel protein biologics as therapeutics. The position requires the supervision of key laboratory procedures and conducting independent research in conjunction with the Principal Investigator, and to train undergraduate, graduate, medical students, postdocs, and visiting scholars. Preferred Additional Knowledge, Skills, and Abilities Desired: Experience with biochemistry and molecular biology techniques and knowledge of reporter assay design and development. Previous experience culturing human cells in vitro and working with animal models of cancer. Demonstrated ability to work independently and in a team; specifically, the candidate must be able to design and execute properly controlled biological experiments independently. Preference will be given to candidates with a background in signal transduction pathways and cancer biology. Excellent written and verbal communication skills and exceptional time management and a PhD with minimum four years postdoctoral experience is desired. Job Duties: Develop and manage multiple scientific projects aimed at understanding the mechanisms of RAS-mediated transformation and tumor development; discovering/developing potential new anti-RAS therapeutics. This includes training and oversight of technical personnel and students to assist in these projects. 35% Design and execution of experiments including cell culture assays, molecular biology techniques such as SDS-PAGE, immunoprecipitation and Western blot analysis, DNA cloning and preparation; recombinant protein production and purification; high-throughput screening assays. 35% Cooperate with fellow lab members to maintain a clean and functioning lab environment including maintenance of shared equipment and resources. 15% Draft manuscripts for publication including primary research articles, reviews, and book chapters. 10% Attend and present findings at national and international scientific meetings. 5% Additional Job Description Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 30 lbs., unassisted. (Frequent) Ability to lift objects, up to 30 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 30 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 50 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 30 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent) Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required. If you like working with energetic enthusiastic individuals, you will enjoy your career with us! The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need. Medical University of South Carolina participates in the federal E-Verify program to confirm the identity and employment authorization of all newly hired employees. For further information about the E-Verify program, please click here: http://www.uscis.gov/e-verify/employees

Keywords: Medical University of South Carolina, Goose Creek , UNIV - Staff Scientist I - Department of Biochemistry, Science, Research & Development , Charleston, South Carolina